Central Strip
Bellagio, Caesars, Paris, LINQ, and nearby attractions work well when you want classic Strip energy with minimal repositioning.
Four hours in Vegas
Do one compact Vegas thing well.
Four hours disappears fast. Stay geographically tight and do not build a cross-town scavenger hunt.
Fast answer
Pick one zone: central Strip, south Strip, north Strip, or Fremont. Do not try to do all of Las Vegas.
Downtown
Fremont can fill a compact block better than bouncing between distant Strip resorts.
One ticketed anchor
If a show or attraction is the point, make that the anchor and keep everything else close by.
Keep deciding